König research group

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Dr. Jörg König, PhD

Cellular models for the analysis of protein-mediated transport

Transport processes across biomembranes are important for the uptake, the distribution, and the elimination of drugs. In the focus of our research are cellular models for investigating the molecular nature of human uptake transporters and export pumps. Basis of these cellular models are established cell lines recombinantly expressing the respective transport protein. We used single-transfected cell lines for the analysis of an uptake transporter or an export pump and double-transfected cell lines simultaneously expressing an uptake transporter together with an export pump for the analysis of vectorial transport processes.
Our research mainly focuses on the following topics:
- what are the functional consequences of genetic variations (mutations or polymorphisms) in genes encoding transport proteins.
- elucidating the role of transport proteins in drug-drug interactions.